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产品信息
PA5-117065
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human NR2C1 (NP_0032882)
偶联物
形式
Liquid
浓度
1.57 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901695
产品详细信息
Positive Samples: HL-60, A-549, 22Rv1, SW480, Mouse ovary
Immunogen sequence: MATIEEIAHQ IIEQQMGEIV TEQQTGQKIQ IVTALDHNTQ GKQFILTNHD GSTPSKVILA RQDSTPGKVF LTTPDAAGVN QLFFTTPDLS AQHLQLLTDN SPDQGPNKVF DLCVVCGDKA SGRHYGAVTC EGCKGFFKRS IRKNLVYSCR GSKDCIINKH HRNRCQYCRL QRCIAFGMKQ DSVQCERKPI EVSREKSSNC AASTEKIYIR KDLRSPLTAT PTFVTDSEST RSTGLLDSGM
靶标信息
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 80-3 cNDA; early embryonic nuclear receptor; mTR2; nr2c1; Nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group C isoform; nuclear receptor subfamily 2, group C, member 1; nuclear receptor subfamily 2, group H, member 1; Orphan nuclear receptor TR2; orphan receptor, TR2-11; Testicular receptor 2; TR2 nuclear hormone receptor
基因别名: 4831444H07Rik; 80.3; Eenr; NR2C1; TR2; Tr2-11
UniProt ID: (Human) P13056, (Mouse) Q505F1
Entrez Gene ID: (Human) 7181, (Mouse) 22025
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid hormone receptor activity
receptor activity
protein binding
zinc ion binding
protein homodimerization activity
histone deacetylase binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
metal ion binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
steroid hormone mediated signaling pathway
positive regulation of retinoic acid receptor signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
