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产品信息
H00026146-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TRAF3IP1 (AAH59174, 1 a.a. approximately 625 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK GLYTDAEMKS DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE PERTNELLQI IGKCCLNKLS SDDAVRRVLA GEKGEVKGRA SLTSRSQELD NKNVREEESR VHKNTEDRGD AEIKERSTSR DRKQKEELKE DRKPREKDKD KEKAKENGGN RHREGERERA KARARPDSER QKDRGNRERD RDSERKKETE RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK NSVEGDSTSD AEGDAGPAGQ DKSEVPETPE IPNELSSNIR RIPRPGSARP APPRVKRQDS MEALQMDRSG SGKTVSNVIT ESHNSDNEED DQFVVEAAPQ LSEMSEIEMV TAVELEEEEK HGGLVKKILE TKKDYEKLQQ SPKPGEKERS LFESAWKKEK DIVSKEIEKL RTSIQTLCKS ALPLGKIMDY IQEDVDAMQN ELQMWHSENR QHAEALQQEQ RITDCAVEPL KAELAELEQL IKDQQDKICA VKANILKNEE KIQKMVYSIN LTSRR
靶标信息
Tumor necrosis factor receptor (TNFR) superfamily members transmit signals regulating proliferation, differentiation and apoptosis in various types of cells. TNFR-associated factors (TRAFs) are a family of proteins that were initially discovered as downstream signal transducers of the TNFR superfamily. TRAF3 contains an N-terminal ring finger/zinc finger region that is thought to be essential for downstream signaling. MIP-T3 is associated with TRAF3. MIP-T3 binds to taxol-stabilized microtubules and to tubulin in vitro, and MIP-T3 recruits TRAF3 to microtubules when both proteins are overexpressed. The MIP-T3/TRAF3 interaction requires the coiled-coil TRAF-N domain of TRAF3. This interaction may provide a novel mechanism in sequestering TRAF3 to the cytoskeletal network.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: interleukin 13 receptor alpha 1-binding protein-1; Interleukin-13 receptor alpha 1-binding protein 1; Intraflagellar transport protein 54 homolog; microtubule interacting protein that associates with TRAF3; Microtubule-interacting protein associated with TRAF3; microtubule-interacting protein that associates with TRAF3; MIP-T3; TNF receptor-associated factor 3 interacting protein 1; TRAF3-interacting protein 1
基因别名: IFT54; MIP-T3; MIPT3; SLSN9; TRAF3IP1
UniProt ID: (Human) Q8TDR0
Entrez Gene ID: (Human) 26146
morphogenesis of a polarized epithelium
kidney development
negative regulation of protein phosphorylation
neural tube patterning
embryonic camera-type eye development
negative regulation of protein complex assembly
negative regulation of type I interferon production
negative regulation of interferon-beta production
embryonic heart tube development
post-anal tail morphogenesis
intraciliary transport
cilium assembly
embryonic digit morphogenesis
negative regulation of defense response to virus
regulation of microtubule cytoskeleton organization
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
