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TRAIL-R2 (DR5) Antibody (PA5-119077) in IHC (P)
Immunohistochemistry analysis of CD262 (DR5) in paraffin-embedded Mouse Cerebrum tissue. Samples were incubated with polyclonal antibody (Product # PA5-119077) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
产品信息
PA5-119077
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Death receptor 5. The antigen corresponds to amino acid range 233-367 of the target protein.
偶联物
形式
Liquid
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903577
靶标信息
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD262; Death receptor 5; dr-5; KILLER/DR5 TRAIL death-inducing receptor; MK; sCD262; soluble CD262; Tumor necrosis factor receptor superfamily member 10B
基因别名: DR5; KILLER; Ly98; MK; Tnfrsf10b; TRAILR2; TRICK2A; TRICK2B; TRICKB
UniProt ID: (Mouse) Q9QZM4
Entrez Gene ID: (Mouse) 21933
