Invitrogen

TRAK1 Polyclonal Antibody

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TRAK1 Antibody (PA5-44180) in WB

Western blot analysis of human HT1080 cell lysate using an anti-TRAK1 polyclonal antibody (Product # PA5-44180).

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产品信息

PA5-44180

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the middle region of human TRAK1

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2576489

产品详细信息

Peptide sequence: IYGYDHDDWL HTPLISPDAN IDLTTEQIEE TLKYFLLCAE RVGQMTKTYN

Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%; Zebrafish: 86%

靶标信息

Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19.

Journal of cell science

Majstrowicz K,Honnert U,Nikolaus P,Schwarz V,Oeding SJ,Hemkemeyer SA,Bähler M

PA5-44180 was used in Western Blot to investigate which mitochondrial and cellular processes depend on the coordination of Myo19 and microtubule-based motor activities.

Sat May 15 00:00:00 UTC 2021

Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19.

Journal of cell science

Majstrowicz K,Honnert U,Nikolaus P,Schwarz V,Oeding SJ,Hemkemeyer SA,Bähler M

PA5-44180 was used in Western Blot to investigate which mitochondrial and cellular processes depend on the coordination of Myo19 and microtubule-based motor activities.

Sat May 15 00:00:00 UTC 2021

Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors.

Nature communications

Fenton AR,Jongens TA,Holzbaur ELF

PA5-44180 was used in Western Blot to investigate if TRAK2 robustly activates kinesin-1 for transport toward the microtubule plus-end through single-molecule imaging of cell lysates.

Wed Jul 28 00:00:00 UTC 2021

Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.

Journal of cell science

Oeding SJ,Majstrowicz K,Hu XP,Schwarz V,Freitag A,Honnert U,Nikolaus P,Bähler M

PA5-44180 was used in Western Blotting to suggest that Miro1 and Miro2 coordinate microtubule- and actin-based mitochondrial movement.

Mon Sep 10 00:00:00 UTC 2018

生物信息学

蛋白别名: 106 kDa O-GlcNAc transferase-interacting protein; milton homolog 1; O-linked N-acetylglucosamine transferase interacting protein 106; OGT(O-Glc-NAc transferase)-interacting protein 106 KDa; Protein Milton; Trafficking kinesin-binding protein 1; trafficking protein, kinesin binding 1

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基因别名: KIAA1042; MILT1; OIP106; TRAK1

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UniProt ID: (Human) Q9UPV9

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Entrez Gene ID: (Human) 22906

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功能

protein binding GABA receptor binding membrane traffic protein

参与通路

regulation of transcription from RNA polymerase II promoter protein O-linked glycosylation protein targeting endosome to lysosome transport