Invitrogen

TRAP1 Polyclonal Antibody

TRAP1 Antibody in Immunocytochemistry (ICC/IF)

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TRAP1 Antibody (PA5-96201) in ICC/IF

Immunofluorescence analysis of TRAP1 in NIH-3T3 cells. Samples were incubated with TRAP1 Polyclonal antibody (Product # PA5-96201) using a dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

TRAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-96201

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:50-1:200

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 445-704 of human TRAP1 (NP_0573762)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.38 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2808003

产品详细信息

Positive Samples: SW620, MCF7, Jurkat, BxPC-3, Mouse kidney, Mouse skeletal muscle, Mouse heart, Mouse brain; Cellular Location: Mitochondrion, Mitochondrion inner membrane, Mitochondrion matrix

Immunogen sequence: GLFMREGIVT ATEQEVKEDI AKLLRYESSA LPSGQLTSLS EYASRMRAGT RNIYYLCAPN RHLAEHSPYY EAMKKKDTEV LFCFEQFDEL TLLHLREFDK KKLISVETDI VVDHYKEEKF EDRSPAAECL SEKETEELMA WMRNVLGSRV TNVKVTLRLD THPAMVTVLE MGAARHFLRM QQLAKTQEER AQLLQPTLEI NPRHALIKKL NQLRASEPGL AQLLVDQIYE NAMIAAGLVD DPRAMVGRLN ELLVKALERH

靶标信息

The 90 kDa heat shock protein (hsp90) family of molecular chaperones is a highly conserved family of proteins that play an important physiological role. Hsp90 is involved in numerous cellular processes but is best known for its association with signal transduction machinery. A recently cloned homolog of hsp90 is the tumor necrosis factor receptor-associated protein (TRAP1). Like hsp90, TRAP1 is found to be associated with numerous proteins involved in diverse actions. Immunofluorescence data has shown TRAP1 to be localized in the mitochondria of mammalian cells. This observation and the fact that TRAP1 is shown to have a mitochondrial targeting presequence strongly implicates TRAP1 as a mitochondrial matrix protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Heat shock protein 75 kDa, mitochondrial; Heat shock protein family C member 5; HSP 75; testicular tissue protein Li 209; TNF receptor-associated protein 1; TNFR-associated protein 1; TRAP-1; tumor necrosis factor type 1 receptor associated protein; Tumor necrosis factor type 1 receptor-associated protein

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基因别名: 2410002K23Rik; HSP 75; HSP75; HSP90L; HSPC5; TRAP-1; TRAP1

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UniProt ID: (Human) Q12931, (Rat) Q5XHZ0, (Mouse) Q9CQN1

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Entrez Gene ID: (Human) 10131, (Rat) 287069, (Mouse) 68015

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功能

tumor necrosis factor receptor binding protein binding ATP binding protein kinase binding poly(A) RNA binding unfolded protein binding nucleotide binding Hsp90 family chaperone

参与通路

response to stress translational attenuation chaperone-mediated protein folding negative regulation of cellular respiration negative regulation of reactive oxygen species biosynthetic process negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide protein folding negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway