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TRF1 Antibody (PA5-87358) in IHC (P)
Immunohistochemistry analysis of TRF1 in paraffin-embedded human gastric cancer. Samples were incubated with TRF1 Polyclonal antibody (Product # PA5-87358) using a dilution of 1:200 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-87358
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 52-275 of human TERF1 (NP_0595232)
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804090
产品详细信息
Positive Samples: Mouse eye; Cellular Location: Chromosome, Cytoplasm, Nucleus, cytoskeleton, spindle, telomere
Immunogen sequence: VGAPEEEEEE EEDAGLVAEA EAVAAGWMLD FLCLSLCRAF RDGRSEDFRR TRNSAEAIIH GLSSLTACQL RTIYICQFLT RIAAGKTLDA QFENDERITP LESALMIWGS IEKEHDKLHE EIQNLIKIQA IAVCMENGNF KEAEEVFERI FGDPNSHMPF KSKLLMIISQ KDTFHSFFQH FSYNHMMEKI KSYVNYVLSE KSSTFLMKAA AKVVESKRTR TITSQ
靶标信息
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ41416; NIMA-interacting protein 2; Telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat binding factor 1; Telomeric repeat-binding factor 1; TTAGGG repeat-binding factor 1
基因别名: hTRF1-AS; PIN2; t-TRF1; TERF1; TRBF1; TRF; TRF1
UniProt ID: (Human) P54274
Entrez Gene ID: (Human) 7013, (Rat) 297758
DNA binding
double-stranded telomeric DNA binding
telomerase activity
protein binding
DNA binding, bending
telomeric DNA binding
protein homodimerization activity
ubiquitin binding
G-rich strand telomeric DNA binding
molecular_function
chromatin binding
microtubule binding
protein heterodimerization activity
telomere maintenance
telomere maintenance via telomerase
mitotic nuclear division
negative regulation of DNA replication
telomere capping
telomeric loop formation
negative regulation of telomere maintenance via telomerase
negative regulation of telomere maintenance via semi-conservative replication
response to drug
meiotic telomere clustering
cell division
negative regulation of telomerase activity
positive regulation of telosome assembly
negative regulation of establishment of protein localization to telomere
negative regulation of establishment of RNA localization to telomere
negative regulation of establishment of macromolecular complex localization to telomere
G2/M transition of mitotic cell cycle
obsolete age-dependent telomere shortening
mitotic spindle assembly checkpoint
obsolete telomere maintenance via telomere shortening
positive regulation of microtubule polymerization
positive regulation of apoptotic process
positive regulation of mitotic nuclear division
positive regulation of mitotic cell cycle
protein homooligomerization
