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TRIC-A (TMEM38A) Antibody (ATC-002-200UL) in ICC/IF
Expression of TRIC-A in mouse muscle myoblast (C2C12) cell line - Immunocytochemical staining of mouse paraformaldehyde-fixed and permeabilized muscle myoblast (C2C12) cell line. A. Cells were stained with Anti-TRIC-A (TMEM38A) Antibody (#ATC-002), (1:200) followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Nuclear staining using DAPI as the counterstain (blue). C. Merged images of pane... View More
产品信息
ATC-002-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)DNHGAPHGMGLGTQHS, corresponding to amino acid residues 259-274 of rat TRIC-A, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 27 kDa sarcoplasmic reticulum protein; Mitsugumin-33A; Mitsugumin33A; sarcoplasmic reticulum protein 27; SPR-27; tmem38a {ECO:0000250|UniProtKB:Q3TMP8}; Transmembrane protein 38A; TRIC-A; TRICA; Trimeric intracellular cation channel type A
基因别名: 1110001E17Rik; AI413399; mg33a; RGD1307901; Srp-27; Tmem38a; TRIC-A
UniProt ID: (Mouse) Q3TMP8, (Rat) A6ZIQ8
Entrez Gene ID: (Mouse) 74166, (Rat) 306327
