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产品信息
PA5-51964
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2648915
产品详细信息
Immunogen sequence: NEVVKECQEK LQVALQRLIK EDQEAEKLED DIRQERTAWK NYIQIERQKI LKGFNEMRVI LDNEEQRELQ KLEEGEVNVL DNLAAATDQL VQQRQDASTL ISDLQRRLRG SSVEMLQDVI DVMKRSESWT LKKPKSVSKK LKSVFRV
Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 54%.
靶标信息
TRIM22 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. It localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 50 kDa-stimulated trans-acting factor; E3 ubiquitin-protein ligase TRIM22; RING finger protein 94; RING-type E3 ubiquitin transferase TRIM22; Staf-50; stimulated trans-acting factor (50 kDa); tripartite binding motif 22; tripartite motif protein TRIM22; tripartite motif-containing 22; Tripartite motif-containing protein 22
基因别名: GPSTAF50; RNF94; STAF50; TRIM22
UniProt ID: (Human) Q8IYM9
Entrez Gene ID: (Human) 10346
transcription, DNA-templated
regulation of transcription, DNA-templated
immune response
response to virus
positive regulation of autophagy
protein ubiquitination
regulation of protein localization
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
defense response to virus
interferon-gamma-mediated signaling pathway
protein trimerization
negative regulation of nucleic acid-templated transcription
