Invitrogen

TRIM31 Polyclonal Antibody

TRIM31 Antibody in Immunohistochemistry (IHC)

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TRIM31 Antibody (PA5-40961) in IHC

Immunohistochemistry analysis of human kidney tissue using an anti-TRIM31 polyclonal antibody (Product # PA5-40961).

TRIM31 Antibody in Surface plasmon resonance (SPR)

TRIM31 Antibody in Western Blot, Immunoprecipitation (WB, IP)

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产品信息

PA5-40961

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

查看2篇已发表文章 2篇已发表文章

免疫组化 (IHC)

5 µg/mL

免疫沉淀 (IP)

查看1篇已发表文章 1篇已发表文章

Surface plasmon resonance (SPR)

Assay-dependent

产品规格

种属反应

Human, Mouse

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the N-terminal of human TRIM31 (aa 117-166).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2605611

产品详细信息

Peptide sequence: CRESKDHKSH NVSLIEEAAQ NYQGQIQEQI QVLQQKEKET VQVKAQGVHR

Sequence homology: Cow: 79%; Human: 100%; Mouse: 86%; Rabbit: 93%

靶标信息

TRIM31 encodes for a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes.

Nature communications

Xu M,Tan J,Dong W,Zou B,Teng X,Zhu L,Ge C,Dai X,Kuang Q,Zhong S,Lai L,Yi C,Tang T,Zhao J,Wang L,Liu J,Wei H,Sun Y,Yang Q,Li Q,Lou D,Hu L,Liu X,Kuang G,Luo J,Xiong M,Feng J,Zhang C,Wang B

PA5-40961 was used in Western Blot to suggest that Trim31 is an endogenous inhibitor of Rhbdf2 and downstream cascades in the pathogenic process of steatohepatitis and that it may serve as a feasible therapeutical target for the treatment of NAFLD/NASH and associated metabolic disorders.

Fri Feb 25 00:00:00 UTC 2022

The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes.

Nature communications

Xu M,Tan J,Dong W,Zou B,Teng X,Zhu L,Ge C,Dai X,Kuang Q,Zhong S,Lai L,Yi C,Tang T,Zhao J,Wang L,Liu J,Wei H,Sun Y,Yang Q,Li Q,Lou D,Hu L,Liu X,Kuang G,Luo J,Xiong M,Feng J,Zhang C,Wang B