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TRPC6 Antibody (PA5-96955) in IHC (P)
Immunohistochemistry analysis of TRPC6 in paraffin-embedded human esophageal cancer. Samples were incubated with TRPC6 Polyclonal antibody (Product # PA5-96955) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-96955
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 466-565 of human TRPC6 (NP_0046122)
偶联物
形式
Liquid
浓度
0.57 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808757
产品详细信息
Positive Samples: 293T, mouse lung, mouse brain, rat brain; Cellular Location: Membrane, Multi-pass membrane protein
Immunogen sequence: EGTKLLPNET STDNAKQLFR MKTSCFSWME MLIISWVIGM IWAECKEIWT QGPKEYLFEL WNMLDFGMLA IFAASFIARF MAFWHASKAQ SIIDANDTLK
靶标信息
Trpc6 forms a receptor-activated calcium channel in the cell membrane. The Trpc6 channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of the Trpc6 channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in the Trpc6 gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). Further, Trpc6 is a member of the mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the ″canonical TRP″ (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, Trpc6 acts as a non-selective store-independent receptor-activated cation channel. Trpc6 is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo. Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium entry channel; FLJ11098; FLJ14863; focal segmental glomerulosclerosis 2; HGNC:12338; Short transient receptor potential channel 6; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; TRP-6; trp6A; TrpC6
基因别名: AV025995; FSGS2; LLHWJM002; LLHWJM003; LLHWJM004; mtrp6; TRP-6; TRP6; TRPC6; Trrp6
UniProt ID: (Human) Q9Y210, (Mouse) Q61143
Entrez Gene ID: (Human) 7225, (Rat) 89823, (Mouse) 22068
cation transport
manganese ion transport
positive regulation of cytosolic calcium ion concentration
single fertilization
aging
positive regulation of peptidyl-threonine phosphorylation
platelet activation
neuron differentiation
positive regulation of ion transmembrane transporter activity
positive regulation of neuron differentiation
negative regulation of dendrite morphogenesis
regulation of cytosolic calcium ion concentration
positive regulation of calcium ion transport
cellular response to hydrogen peroxide
calcium ion transmembrane transport
cellular response to hypoxia
transport
ion transport
calcium ion transport
transmembrane transport
