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产品信息
PA5-34283
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 17 amino acid peptide from N-Terminus of human TRPM4.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551635
产品详细信息
Percent identity with other species by BLAST analysis: Human (100%); Chimpanzee, Gorilla, Orangutan, Monkey, Mouse (94%); Gibbon, Galago, Rat, Dog (88%); Marmoset, Elephant, Panda, Bovine, Pig (82%).
Use in IHC with formalin-fixed paraffin-embedded tissues requires proteinase K digestion for antigen retrieval.
靶标信息
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium-activated non-selective cation channel 1; H LTrpC-4; hTRPM4; Long transient receptor potential channel 4; LTrpC-4; Melastatin-4; Transient receptor potential cation channel subfamily M member 4; transient receptor potential cation channel, subfamily M, member 4
基因别名: hTRPM4; LTRPC4; PFHB1B; TRPM4; TRPM4B
UniProt ID: (Human) Q8TD43
Entrez Gene ID: (Human) 54795
adaptive immune response
dendritic cell chemotaxis
regulation of T cell cytokine production
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
positive regulation of heart rate
protein sumoylation
negative regulation of bone mineralization
sodium ion transmembrane transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
vasoconstriction
positive regulation of fat cell differentiation
negative regulation of osteoblast differentiation
positive regulation of vasoconstriction
cardiac conduction
calcium ion transmembrane transport
positive regulation of canonical Wnt signaling pathway
positive regulation of atrial cardiac muscle cell action potential
positive regulation of adipose tissue development
positive regulation of regulation of vascular smooth muscle cell membrane depolarization
