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TRPM7 Antibody (PA5-15302) in IHC (P)
Immunohistochemistry analysis of TRPM7 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with TRPM7 polyclonal antibody (Product # PA5-15302) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepa... View More
产品信息
PA5-15302
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 1821-1850 amino acids from the C-terminal region of human TRPM7 (CHAK1)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation, Size-exclusion - Dialysis
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2241017
靶标信息
TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Channel kinase 1; Channel-kinase 1; FLJ20117; Long transient receptor potential channel 7; LTRPC ion channel family member 7; LTrpC-7; tr; Transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel, subfamily M, member 7; transient receptor potential M7; Transient receptor potential-phospholipase C-interacting kinase; transient receptor potential-related protein, ChaK; TRMP7; TRP PLIK; TRP-PLIK
基因别名: 2310022G15Rik; 4833414K03Rik; 5033407O22Rik; ALSPDC; CHAK; CHAK1; Ltpr7; LTrpC-7; LTRPC7; TRP-PLIK; TRPM7; TRPPLIK
UniProt ID: (Human) Q96QT4, (Mouse) Q925B2
Entrez Gene ID: (Human) 54822, (Mouse) 58800
actin binding
protein serine/threonine kinase activity
calcium channel activity
ATP binding
myosin binding
metal ion binding
nucleotide binding
protein kinase activity
ion channel activity
cation channel activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
ion channel
transporter
cellular magnesium ion homeostasis
calcium-dependent cell-matrix adhesion
actomyosin structure organization
protein autophosphorylation
protein tetramerization
necroptotic process
calcium ion transmembrane transport
protein phosphorylation
transport
ion transport
cation transport
calcium ion transport
memory
programmed cell death
phosphorylation
positive regulation of apoptotic process
transmembrane transport
