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TRPV1 (VR1) (extracellular) Antibody (ACC-029-AG-50UL) in ICC/IF
Expression of TRPV1 in rat PC12 cells - Cell surface detection of TRPV1 in intact living Pheochromocytoma (PC12) cells. A. Extracellular staining of cells using Anti-Rat TRPV1 (VR1) (extracellular)-ATTO Fluor-488 Antibody (#ACC-029-AG), (1:25), (green). B. Live view of the cell. C. Merge images of A and B.
产品信息
ACC-029-AG-50UL
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)NSLPMESTPHK*SRGS,corresponding to amino acid residues 605-619 of rat TRPV1 with replacement of cysteine 616 (C616) with serine (*S), 3rd extracellular loop
偶联物
激发/发射光谱
501/523 nm
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
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生物信息学
蛋白别名: Capsaicin receptor; DKFZp434K0220; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential vanilloid 1 supraoptic nucleus; TrpV1; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor
基因别名: Trpv1; TRPV1_SON; VR.5'sv; Vr1; Vr1l; Vr1l1
UniProt ID: (Rat) O35433
Entrez Gene ID: (Rat) 83810
transmembrane signaling receptor activity
ion channel activity
excitatory extracellular ligand-gated ion channel activity
cation channel activity
calcium channel activity
protein binding
calmodulin binding
ATP binding
cation transmembrane transporter activity
ligand-gated ion channel activity
calcium-release channel activity
chloride channel regulator activity
identical protein binding
phosphoprotein binding
ion channel
temperature homeostasis
fever generation
microglial cell activation
diet induced thermogenesis
peptide secretion
lipid metabolic process
calcium ion transport
inflammatory response
signal transduction
positive regulation of cytosolic calcium ion concentration
response to pH
response to heat
response to organonitrogen compound
glutamate secretion
urinary bladder smooth muscle contraction
sensory perception of pain
ion transmembrane transport
positive regulation of apoptotic process
response to peptide hormone
positive regulation of nitric oxide biosynthetic process
response to pain
behavioral response to pain
sensory perception of mechanical stimulus
thermoception
detection of chemical stimulus involved in sensory perception of pain
smooth muscle contraction involved in micturition
positive regulation of gastric acid secretion
calcium ion transmembrane transport
cellular response to alkaloid
cellular response to ATP
cellular response to cytokine stimulus
cellular response to tumor necrosis factor
cellular response to growth factor stimulus
cellular response to temperature stimulus
negative regulation of establishment of blood-brain barrier
cellular response to nerve growth factor stimulus
