Invitrogen

TSH Receptor Monoclonal Antibody (4C1)

TSH Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TSH Receptor Antibody (MA5-16519) in IHC (P)

Immunohistochemical analysis of TSH Receptor in paraffin embedded human thyroid. Samples were incubated in TSH Receptor Monoclonal antibody (Product # MA5-16519).

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产品信息

MA5-16519

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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免疫组化（石蜡） (IHC (P))

1:1,000-1:2,000

免疫组化（冰冻） (IHC (F))

Assay-dependent

流式细胞分析 (Flow)

1:100-1:1,000

免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Human

已发表种属

Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

4C1

抗原

External domain of human TSH receptor.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2538030

产品详细信息

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL. A suggested positive control for immunohistochemical applications is thyroid gland. This product does not require protein digestion pre-treatment of paraffin embedded sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin embedded sections.

靶标信息

TSH Receptor gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

MicroRNA-577 aggravates bone loss and bone remodeling by targeting thyroid stimulating hormone receptor in hyperthyroid-associated osteoporosis.

Environmental toxicology

Xu T,Zhou P,Li H,Ding Q,Hua F

MA5-16519 was used in Western Blot to explore the role of TSHR and its upstream microRNA (miRNA) in hyperthyroid-associated osteoporosis.

Tue Mar 01 00:00:00 UTC 2022

生物信息学

蛋白别名: MGC141920; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2; Thyroid-stimulating hormone receptor; Thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH-R

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基因别名: CHNG1; hTSHR-I; LGR3; TSHR

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UniProt ID: (Human) P16473

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Entrez Gene ID: (Human) 7253

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功能

thyroid-stimulating hormone receptor activity protein binding G-protein coupled peptide receptor activity G-protein coupled receptor

参与通路

G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity cell-cell signaling nervous system development positive regulation of cell proliferation hormone-mediated signaling pathway thyroid-stimulating hormone signaling pathway