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Product Details
PA5-34344
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid synthetic peptide near the amino terminus of human TSHZ3
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551696
Product Specific Information
A suggested positive control is mouse brain tissue lysate.
PA5-34344 can be used with blocking peptide PEP-1387.
Target Information
The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. In mice, the known three TSHZ proteins are expressed in distinct patterns in the developing and adult brain, suggesting that they play a role in the establishment of regional identity and specification of cell types within the brain. Both TSHZ3 and TSHZ1 have been found to interact with FE65, an adapter protein that binds to the amyloid protein precursor (APP) in neurons. Together with SET, a component of the inhibitor of acetyl transferase, and histone deacetylases, these proteins formed a gene-silencing complex whose target includes caspase-4. Recent experiments have also suggested this family of proteins may be involved in carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: teashirt 3; Teashirt homolog 3; teashirt zinc finger family member 3; Zinc finger protein 537
Gene Aliases: A630038G13Rik; KIAA1474; mKIAA1474; teashirt3; TSH3; TSHZ3; Zfp537; ZNF537
UniProt ID: (Human) Q63HK5, (Rat) D3ZKB9, (Mouse) Q8CGV9
Entrez Gene ID: (Human) 57616, (Rat) 308523, (Mouse) 243931
metanephros development
ureteric bud development
in utero embryonic development
regulation of respiratory gaseous exchange by neurological system process
transcription, DNA-templated
lung development
negative regulation of transcription, DNA-templated
smooth muscle tissue development
musculoskeletal movement
sensory perception of touch
positive regulation of smooth muscle cell differentiation
kidney morphogenesis
ureteric peristalsis
ureter smooth muscle cell differentiation
kidney smooth muscle cell differentiation
regulation of transcription, DNA-templated
multicellular organism development
regulation of gene expression
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