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产品信息
PA5-57294
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2649046
产品详细信息
Immunogen sequence: ALAHEPVNEL SALMEDGRCQ VLLAKVYSKM EKLGDAITAL QQARELQARV LKRVQMEQPD AVPAQKHLAA EICAEIAKHS VAQRDYE
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.
靶标信息
The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TTC21B (tetratricopeptide repeat domain 21B), also known as THM1, is a 1,316 amino acid protein that contains 19 TPR repeats and belongs to the TTC21 family. Localizing to cytoplasm and cytoskeleton, TTC21B exists as two alternatively spliced isoforms and is thought to negatively regulate Shh signal transduction. TTC21B may also be involved in retrograde intraflagellar transport in cilia, and is encoded by a gene that maps to human chromosome 2q24.3.
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生物信息学
蛋白别名: Intraflagellar transport 139 homolog; putative protein product of Nbla10696; Tetratricopeptide repeat protein 21B; TPR repeat protein 21B
基因别名: ATD4; IFT139; IFT139B; JBTS11; KIAA1992; Nbla10696; NPHP12; SRTD4; THM1; TTC21B
UniProt ID: (Human) Q7Z4L5
Entrez Gene ID: (Human) 79809
regulation of transcription from RNA polymerase II promoter
smoothened signaling pathway
regulation of smoothened signaling pathway
ventricular system development
forebrain dorsal/ventral pattern formation
intraciliary retrograde transport
intraciliary transport involved in cilium morphogenesis
cilium morphogenesis
protein localization to cilium
