Invitrogen

TTYH2 Polyclonal Antibody

TTYH2 Antibody in Immunohistochemistry (IHC)

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TTYH2 Antibody (PA5-34395) in IHC

Immunohistochemistry of TTYH2 in human kidney tissue with TTYH2 Polyclonal Antibody (Product # PA5-34395) at 2.5 µg/mL.

TTYH2 Antibody in Immunocytochemistry (ICC/IF)

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产品信息

PA5-34395

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

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免疫组化 (IHC)

2.5 µg/mL

免疫细胞化学 (ICC/IF)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A 14 amino acid synthetic peptide near the amino terminus of human TTYH2

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2551747

产品详细信息

A suggested positive control is human kidney tissue lysate.

PA5-34395 can be used with blocking peptide PEP-1437.

靶标信息

TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2.

Immunity

Lu Q,Liu J,Zhao S,Gomez Castro MF,Laurent-Rolle M,Dong J,Ran X,Damani-Yokota P,Tang H,Karakousi T,Son J,Kaczmarek ME,Zhang Z,Yeung ST,McCune BT,Chen RE,Tang F,Ren X,Chen X,Hsu JCC,Teplova M,Huang B,Deng H,Long Z,Mudianto T,Jin S,Lin P,Du J,Zang R,Su TT,Herrera A,Zhou M,Yan R,Cui J,Zhu J,Zhou Q,Wang T,Ma J,Koralov SB,Zhang Z,Aifantis I,Segal LN,Diamond MS,Khanna KM,Stapleford KA,Cresswell P,Liu Y,Ding S,Xie Q,Wang J

PA5-34395 was used in Western Blotting to identify several C-type lectins (DC-SIGN, L-SIGN, LSECtin, ASGR1, and CLEC10A) and Tweety family member 2 (TTYH2) as glycan-dependent binding partners of the SARS-CoV-2 spike.

Tue Jun 08 00:00:00 UTC 2021

TTYH1 and TTYH2 Serve as LRRC8A-Independent Volume-Regulated Anion Channels in Cancer Cells.

Cells

Bae Y,Kim A,Cho CH,Kim D,Jung HG,Kim SS,Yoo J,Park JY,Hwang EM

PA5-34395 was used in Immunocytochemistry-immunoflourescence to show that TTYH1 and TTYH2 can act as LRRC8A-independent VRACs, suggesting novel therapeutic approaches for VRACs in cancer cells.