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产品信息
PA5-101075
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TUSC2(Accession O75896), corresponding to amino acid residues F52-D102.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850519
产品详细信息
Antibody detects endogenous levels of total TUSC2.
靶标信息
TUSC2 (tumor suppressor candidate 2), also known as FUS1, LGCC or PDAP2, is a 110 amino acid protein that is expressed at high levels in kidney, pancreas, lung, heart and skeletal muscle where it is thought to function as a tumor suppressor. More specifically, TUSC2 inhibits invasive colony formation by inducing G1 cell cycle arrest and ultimately causing apoptosis, thereby preventing tumor growth. The gene encoding TUSC2 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B.
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生物信息学
蛋白别名: Fus-1 protein; Fusion 1 protein; lung cancer candidiate, FUS; PDGFA associated protein 2; PDGFA-associated protein 2; Tumor suppressor candidate 2; TUSC 2
基因别名: 1190001E22Rik; AA407686; C3orf11; FUS1; LGCC; PAP; PDAP2; TUSC2
UniProt ID: (Human) O75896, (Mouse) Q9WVF8
Entrez Gene ID: (Human) 11334, (Mouse) 80385
natural killer cell differentiation
phagocytosis
inflammatory response
cell cycle
cell-cell signaling
cell proliferation
interleukin-15 production
negative regulation of interleukin-17 production
positive regulation of interleukin-10 production
cell maturation
regulation of mitochondrial membrane potential
response to defense-related host reactive oxygen species production
neutrophil mediated killing of gram-negative bacterium
chemokine (C-C motif) ligand 5 production
regulation of reactive oxygen species metabolic process
defense response to Gram-negative bacterium
