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TUT1 Antibody (PA5-116092) in ICC/IF
Immunocytochemistry analysis of TUT1 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-116092). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
产品信息
PA5-116092
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TUT1(Accession Q9H6E5), corresponding to amino acid residues V108-D158.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900726
产品详细信息
Antibody detects endogenous levels of total TUTase.
靶标信息
TUT1 is a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. TUT1 specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation. TUT1 specifically catalyzes uridylylation of U6 snRNA (RNU6; MIM 180692) and is essential for cell proliferation (Trippe et al., 2006 [PubMed 16790842]).[supplied by OMIM].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ21850; FLJ22267; FLJ22347; MGC131987; MGC149809; nuclear speckle targeted phosphatidylinositol 4-phosphate 5-kinase type I-alpha regulated-poly(A) polymerase; nuclear speckle-targeted PIPK1A-regulated-poly(A) polymerase; PAP-associated domain-containing 2; poly(A) polymerase associated domain containing 2; RNA binding motif protein 21; RNA uridylyltransferase; RNA-binding motif protein 21; RNA-binding protein 21; Speckle targeted PIP5K1A-regulated poly(A) polymerase; Star-PAP; terminal uridylyl transferase 1 U6 snRNA-specific; TUTase 6; U6 snRNA-specific terminal uridylyltransferase 1; U6 TUTase; U6-TUTase; up-regulated in lung cancer 6
基因别名: 2700038E08Rik; PAPD2; RBM21; STARPAP; TUT1; TUTase; TUTase6; URLC6
UniProt ID: (Human) Q9H6E5, (Rat) Q3MHT4, (Mouse) Q8R3F9
Entrez Gene ID: (Human) 64852, (Rat) 499314, (Mouse) 70044
RNA binding
mRNA 3'-UTR binding
polynucleotide adenylyltransferase activity
protein binding
ATP binding
enzyme binding
metal ion binding
RNA uridylyltransferase activity
nucleotide binding
nucleic acid binding
transferase activity
nucleotidyltransferase activity
nucleotidyltransferase
transferase
metabolite interconversion enzyme
