Invitrogen

TWIST1 Polyclonal Antibody

查看其他33个TWIST1抗体

产品信息

PA5-68957

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1.0 µg/mL

-

产品规格

种属反应

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide directed towards the middle region of human TWIST1

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2691014

产品详细信息

This target displays homology in the following species: Cow: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%

靶标信息

TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: p ACS3; twist basic helix-loop-helix transcription factor 1; twist gene homolog 1; twist homolog 1; twist-related protein 1

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基因别名: Twist

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Entrez Gene ID: (Rat) 85489

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RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function transcription factor activity, sequence-specific DNA binding transcription factor binding protein domain specific binding protein homodimerization activity bHLH transcription factor binding protein heterodimerization activity E-box binding basic helix-loop-helix transcription factor

negative regulation of transcription from RNA polymerase II promoter ossification osteoblast differentiation in utero embryonic development neuron migration neural tube closure aortic valve morphogenesis mitral valve morphogenesis endocardial cushion morphogenesis cardiac neural crest cell migration involved in outflow tract morphogenesis transcription from RNA polymerase II promoter positive regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of phosphatidylinositol 3-kinase signaling cell differentiation embryonic limb morphogenesis regulation of bone mineralization positive regulation of fatty acid beta-oxidation negative regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production negative regulation of histone phosphorylation negative regulation of histone acetylation embryonic forelimb morphogenesis embryonic hindlimb morphogenesis hindlimb morphogenesis negative regulation of peroxisome proliferator activated receptor signaling pathway odontogenesis embryonic digit morphogenesis negative regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of molecular function negative regulation of cell differentiation negative regulation of osteoblast differentiation negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of skeletal muscle tissue development embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis positive regulation of epithelial cell proliferation palate development bone development cranial suture morphogenesis embryonic camera-type eye formation eyelid development in camera-type eye cardiac neural crest cell development involved in outflow tract morphogenesis cellular response to growth factor stimulus cellular response to hypoxia positive regulation of monocyte chemotactic protein-1 production positive regulation of cell motility negative regulation of oxidative phosphorylation uncoupler activity positive regulation of transcription regulatory region DNA binding negative regulation of cellular senescence positive regulation of interleukin-6 secretion negative regulation of double-strand break repair cell proliferation involved in heart valve development positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation