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产品信息
H00007291-M07
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
4B4
抗原
TWIST1 (NP_000465, 100 a.a. approximately 202 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen sequence: PQSYEELQTQ RVMANVRERQ RTQSLNEAFA ALRKIIPTLP SDKLSKIQTL KLAARYIDFL YQVLQSDELD SKMASCSYVA HERLSYAFSV WRMEGAWSMS ASH
靶标信息
TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-HLH DNA binding protein; bHLHa38; Class A basic helix-loop-helix protein 38; H-twist; p ACS3; twist basic helix-loop-helix transcription factor 1; twist homolog 1; TWIST homolog of drosophila; Twist-related protein 1
基因别名: ACS3; BHLHA38; BPES2; BPES3; CRS; CRS1; CSO; SCS; TWIST; TWIST1
UniProt ID: (Human) Q15672
Entrez Gene ID: (Human) 7291
RNA polymerase II transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
E-box binding
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
ossification
osteoblast differentiation
in utero embryonic development
neuron migration
neural tube closure
aortic valve morphogenesis
mitral valve morphogenesis
endocardial cushion morphogenesis
cardiac neural crest cell migration involved in outflow tract morphogenesis
transcription, DNA-templated
muscle organ development
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
negative regulation of phosphatidylinositol 3-kinase signaling
regulation of bone mineralization
positive regulation of fatty acid beta-oxidation
negative regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor production
negative regulation of histone phosphorylation
negative regulation of histone acetylation
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
negative regulation of peroxisome proliferator activated receptor signaling pathway
outer ear morphogenesis
odontogenesis
embryonic digit morphogenesis
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
negative regulation of skeletal muscle tissue development
embryonic cranial skeleton morphogenesis
positive regulation of epithelial cell proliferation
palate development
cranial suture morphogenesis
embryonic camera-type eye formation
eyelid development in camera-type eye
cellular response to growth factor stimulus
cellular response to hypoxia
positive regulation of monocyte chemotactic protein-1 production
positive regulation of DNA-templated transcription, initiation
positive regulation of cell motility
negative regulation of oxidative phosphorylation uncoupler activity
positive regulation of transcription regulatory region DNA binding
negative regulation of cellular senescence
positive regulation of interleukin-6 secretion
negative regulation of double-strand break repair
cell proliferation involved in heart valve development
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
