Product References
Vitamin D Prevents High Glucose-Induced Lipid Droplets Accumulation in Cultured Endothelial Cells: The Role of Thioredoxin Interacting Protein.
Biomedicines
Scrimieri R,Cazzaniga A,Castiglioni S,Maier JAM
40-3700 was used in Western Blotting to highlight TXNIP as one of the targets of VitD in high glucose-cultured endothelial cells and shed some light on the protective effect of VitD on the endothelium.
Fri Dec 10 00:00:00 UTC 2021
Vitamin D Prevents High Glucose-Induced Lipid Droplets Accumulation in Cultured Endothelial Cells: The Role of Thioredoxin Interacting Protein.
Biomedicines
Scrimieri R,Cazzaniga A,Castiglioni S,Maier JAM
40-3700 was used in Western Blotting to highlight TXNIP as one of the targets of VitD in high glucose-cultured endothelial cells and shed some light on the protective effect of VitD on the endothelium.
Fri Dec 10 00:00:00 UTC 2021
Metformin Protects ARPE-19 Cells from Glyoxal-Induced Oxidative Stress.
Oxidative medicine and cellular longevity
Qu S,Zhang C,Liu D,Wu J,Tian H,Lu L,Xu GT,Liu F,Zhang J
40-3700 was used in Western Blotting to demonstrate that metformin maintained the barrier functions of RPE cells both in vivo and in vitro.
Wed Dec 16 00:00:00 UTC 2020
TXNIP induces growth arrest and enhances ABT263-induced apoptosis in mixed-lineage leukemia-rearranged acute myeloid leukemia cells.
FEBS open bio
Noura M,Matsuo H,Koyama A,Adachi S,Masutani H
Published figure using TXNIP polyclonal antibody (Product # 40-3700) in Western Blot
Sat Aug 01 00:00:00 UTC 2020
Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model.
International journal of molecular sciences
Mohamed IN,Sheibani N,El-Remessy AB
40-3700 was used in Western Blotting to show that a high fat diet (HFD) induces the activation of retinal NOD-like receptor protein (NLRP3)-inflammasome that is associated with enhanced expression and interaction with thioredoxin-interacting protein (TXNIP).
Mon Jun 01 00:00:00 UTC 2020
Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model.
International journal of molecular sciences
Mohamed IN,Sheibani N,El-Remessy AB
40-3700 was used in Western Blotting to show that a high fat diet (HFD) induces the activation of retinal NOD-like receptor protein (NLRP3)-inflammasome that is associated with enhanced expression and interaction with thioredoxin-interacting protein (TXNIP).
Mon Jun 01 00:00:00 UTC 2020
miR-20b and miR-451a Are Involved in Gastric Carcinogenesis through the PI3K/AKT/mTOR Signaling Pathway: Data from Gastric Cancer Patients, Cell Lines and Ins-Gas Mouse Model.
International journal of molecular sciences
Streleckiene G,Inciuraite R,Juzenas S,Salteniene V,Steponaitiene R,Gyvyte U,Kiudelis G,Leja M,Ruzgys P,Satkauskas S,Kupcinskiene E,Franke S,Thon C,Link A,Kupcinskas J,Skieceviciene J
Published figure using TXNIP polyclonal antibody (Product # 40-3700) in Western Blot
Wed Jan 29 00:00:00 UTC 2020
Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate.
Diabetes
Katsu-Jiménez Y,Vázquez-Calvo C,Maffezzini C,Halldin M,Peng X,Freyer C,Wredenberg A,Giménez-Cassina A,Wedell A,Arnér ESJ
40-3700 was used in Western Blotting to study a family with a mutation in the TXNIP gene leading to nondetectable expression of TXNIP protein.
Mon Apr 01 00:00:00 UTC 2019
Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids.
Stem cell reports
Kim H,Park HJ,Choi H,Chang Y,Park H,Shin J,Kim J,Lengner CJ,Lee YK,Kim J
40-3700 was used in Western Blotting to study the pathogenic mechanisms associated with Parkinson's disease-associated LRRK2 mutation.
Tue Mar 05 00:00:00 UTC 2019
Thioredoxin-interacting protein promotes high-glucose-induced macrovascular endothelial dysfunction.
Biochemical and biophysical research communications
Li X,Kover KL,Heruth DP,Watkins DJ,Guo Y,Moore WV,He LG,Zang M,Clements MA,Yan Y
40-3700 was used in Western Blotting to investigate whether thioredoxin-interacting protein promotes endothelial dysfunction seen in Type 1 diabetes mellitus.
Sat Nov 04 00:00:00 UTC 2017
High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress.
World journal of diabetes
Coucha M,Mohamed IN,Elshaer SL,Mbata O,Bartasis ML,El-Remessy AB
Published figure using TXNIP polyclonal antibody (Product # 40-3700) in Western Blot
Wed Feb 15 00:00:00 UTC 2017
Thioredoxin-1 attenuates sepsis-induced cardiomyopathy after cecal ligation and puncture in mice.
The Journal of surgical research
Wilson RL,Selvaraju V,Lakshmanan R,Thirunavukkarasu M,Campbell J,McFadden DW,Maulik N
40-3700 was used in Western Blotting to indicate that overexpression of Trx-1 attenuates cardiac dysfunction during CLP. The mechanism of action may involve reduction of oxidative stress, apoptosis, and vascular permeability through activation of Trx-1/HO-1 and anti-apoptotic protein survivin.
Fri Dec 01 00:00:00 UTC 2017
Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression.
Redox biology
Du RH,Wu FF,Lu M,Shu XD,Ding JH,Wu G,Hu G
40-3700 was used in immunoprecipitation show that UCP2 regulates inflammatory responses in astrocytes and contributes to depression
Sat Oct 01 00:00:00 UTC 2016
Variations of thioredoxin system contributes to increased susceptibility to apoptosis in cardiomyocytes of type 2 diabetic rats.
Acta biochimica et biophysica Sinica
Zhao X,Zhang Y,Li X,Wang R,Jiao X
40-3700 was used in western blot to assess the role of thioredoxin in myocardial injury and apoptosis using diabetic rats.
Tue Apr 01 00:00:00 UTC 2014
Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer.
Molecular cancer
Morrison JA,Pike LA,Sams SB,Sharma V,Zhou Q,Severson JJ,Tan AC,Wood WM,Haugen BR
40-3700 was used in western blot to discuss the role of peroxisome proliferator-activated receptor gamma in anaplastic thyroid cancer and differentiated thyroid cancer.
Wed Mar 19 00:00:00 UTC 2014
Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer.
Molecular cancer
Morrison JA,Pike LA,Sams SB,Sharma V,Zhou Q,Severson JJ,Tan AC,Wood WM,Haugen BR
40-3700 was used in western blot to discuss the role of peroxisome proliferator-activated receptor gamma in anaplastic thyroid cancer and differentiated thyroid cancer.
Wed Mar 19 00:00:00 UTC 2014
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.
Science (New York, N.Y.)
Santagata S,Mendillo ML,Tang YC,Subramanian A,Perley CC,Roche SP,Wong B,Narayan R,Kwon H,Koeva M,Amon A,Golub TR,Porco JA,Whitesell L,Lindquist S
Published figure using TXNIP polyclonal antibody (Product # 40-3700) in Western Blot
Fri Jul 19 00:00:00 UTC 2013
A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
American journal of physiology. Endocrinology and metabolism
Zervou S,Ray T,Sahgal N,Sebag-Montefiore L,Cross R,Medway DJ,Ostrowski PJ,Neubauer S,Lygate CA
40-3700 was used in western blot to identify candidate endogenous creatine transporter inhibitors.
Mon Jul 15 00:00:00 UTC 2013
Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.
Circulation research
Wang XQ,Nigro P,World C,Fujiwara K,Yan C,Berk BC
Published figure using TXNIP polyclonal antibody (Product # 40-3700) in Western Blot
Fri Feb 17 00:00:00 UTC 2012
Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.
Circulation research
Wang XQ,Nigro P,World C,Fujiwara K,Yan C,Berk BC
Published figure using TXNIP polyclonal antibody (Product # 40-3700) in Western Blot
Fri Feb 17 00:00:00 UTC 2012
Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.
Circulation research
Wang XQ,Nigro P,World C,Fujiwara K,Yan C,Berk BC
Published figure using TXNIP polyclonal antibody (Product # 40-3700) in Western Blot
Fri Feb 17 00:00:00 UTC 2012
A role for mitochondria in NLRP3 inflammasome activation.
Nature
Zhou R,Yazdi AS,Menu P,Tschopp J
40-3700 was used in immunohistochemistry (frozen) to demonstrate that the NLRP3 inflammasome senses mitochondrial dysfunction.
Thu Jan 13 00:00:00 UTC 2011
Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-α: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species.
Arteriosclerosis, thrombosis, and vascular biology
World C,Spindel ON,Berk BC
40-3700 was used in western blot to test if TXNIP-TRX trafficking alters the function of endothelial cells exposed to reactive oxygen species.
Mon Aug 01 00:00:00 UTC 2011
Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-α: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species.
Arteriosclerosis, thrombosis, and vascular biology
World C,Spindel ON,Berk BC
40-3700 was used in western blot to test if TXNIP-TRX trafficking alters the function of endothelial cells exposed to reactive oxygen species.
Mon Aug 01 00:00:00 UTC 2011
Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-α: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species.
Arteriosclerosis, thrombosis, and vascular biology
World C,Spindel ON,Berk BC
40-3700 was used in western blot to test if TXNIP-TRX trafficking alters the function of endothelial cells exposed to reactive oxygen species.
Mon Aug 01 00:00:00 UTC 2011
Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
Nature immunology
Zhou R,Tardivel A,Thorens B,Choi I,Tschopp J
40-3700 was used in western blot to report that NLRP3 interacts with thioredoxin-interacting protein and investigate how this interaction modulates secretion of interleukin 1 beta.
Mon Feb 01 00:00:00 UTC 2010
Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
Nature immunology
Zhou R,Tardivel A,Thorens B,Choi I,Tschopp J
40-3700 was used in western blot to report that NLRP3 interacts with thioredoxin-interacting protein and investigate how this interaction modulates secretion of interleukin 1 beta.
Mon Feb 01 00:00:00 UTC 2010
Expression, localization, and function of the thioredoxin system in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN
Advani A,Gilbert RE,Thai K,Gow RM,Langham RG,Cox AJ,Connelly KA,Zhang Y,Herzenberg AM,Christensen PK,Pollock CA,Qi W,Tan SM,Parving HH,Kelly DJ
Wed Apr 01 00:00:00 UTC 2009
Expression, localization, and function of the thioredoxin system in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN
Advani A,Gilbert RE,Thai K,Gow RM,Langham RG,Cox AJ,Connelly KA,Zhang Y,Herzenberg AM,Christensen PK,Pollock CA,Qi W,Tan SM,Parving HH,Kelly DJ
Wed Apr 01 00:00:00 UTC 2009
Expression, localization, and function of the thioredoxin system in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN
Advani A,Gilbert RE,Thai K,Gow RM,Langham RG,Cox AJ,Connelly KA,Zhang Y,Herzenberg AM,Christensen PK,Pollock CA,Qi W,Tan SM,Parving HH,Kelly DJ
Wed Apr 01 00:00:00 UTC 2009
Expression, localization, and function of the thioredoxin system in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN
Advani A,Gilbert RE,Thai K,Gow RM,Langham RG,Cox AJ,Connelly KA,Zhang Y,Herzenberg AM,Christensen PK,Pollock CA,Qi W,Tan SM,Parving HH,Kelly DJ
Wed Apr 01 00:00:00 UTC 2009
Expression, localization, and function of the thioredoxin system in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN
Advani A,Gilbert RE,Thai K,Gow RM,Langham RG,Cox AJ,Connelly KA,Zhang Y,Herzenberg AM,Christensen PK,Pollock CA,Qi W,Tan SM,Parving HH,Kelly DJ
Wed Apr 01 00:00:00 UTC 2009
Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities.
Anti-cancer drugs
Dedes KJ,Dedes I,Imesch P,von Bueren AO,Fink D,Fedier A
40-3700 was used in Western Blotting to investigate the role of vorinostat in the acquisition of tumour multidrug resistance, showing that resistance to vorinostat leads to partial resistance to 'second-generation' histone deacetylase inhibitors.
Mon Jun 01 00:00:00 UTC 2009
