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TYROBP Antibody (MA5-34787) in ICC/IF
Immunofluorescence analysis of TYROBP is performed using THP-1 cells and THP1 differentiated to Macrophages. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with TYROBP Recombinant Rabbit Monoclonal Antibody (JG38-70) (Product # MA5-34787) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary ... View More
产品信息
MA5-34787
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JG38-70
抗原
Recombinant protein within Human DAP12 aa 1-113
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Wet ice
RRID
AB_2848695
产品详细信息
Positive Control: THP-1, K562, human lung cancer tissue.
靶标信息
DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells. DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction. Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice, as well as presenile dementia and bone cysts in humans.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNAX-activation protein 12; KAR-associated protein; Killer-activating receptor-associated protein; TYRO protein tyrosine kinase-binding protein
基因别名: DAP12; KARAP; PLOSL; TYROBP
UniProt ID: (Human) O43914
Entrez Gene ID: (Human) 7305
macrophage activation involved in immune response
neutrophil activation involved in immune response
cellular defense response
signal transduction
integrin-mediated signaling pathway
intracellular signal transduction
innate immune response
regulation of immune response
regulation of osteoclast development
