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TYRP1 Chimeric Antibody (MA5-47827) in Flow
Flow Cytometry analysis of TYRP1 in Mouse splenocytes (A), B16F10 murine melanoma cells (B), KPC3 pancreas carcinoma cells (C) and KPC3 cells transfected with the Trp1 gene (D) using TYRP1 Chimeric Monoclonal Antibody (Product # MA5-47827). Cells were fixed using 2% PFA, permeabilized using 0.5% Triton and were subject to a primary treatment of either buffer, mouse-IgG1 chimeric 2C11 or mouse-IgG1 chimeric TA99 (indicated above plots) before a secondary treatment with buffer, goat anti-mouse Ig-allophycocyanin (G-aM Ig-APC) or anti-His Tag... View More
产品信息
MA5-47827
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
TA99
抗原
70-75 kDa pigmentation-associated glycoprotein in human melanoma cell lines.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3074274
产品详细信息
Specificity: Binds Tyrosinase-related protein-1 (TRP-1), a 70-75k enzyme located in melanocytes, which are specialized cells that produce a pigment called melanin, helping to stabilize tyrosinase, which is the enzyme responsible for the first step in melanin production and determine the shape of melanosomes, which are the structures in melanocytes where melanin is produced.
靶标信息
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5,6-dihydroxyindole-2-carboxylic acid oxidase; Catalase B; DHICA oxidase; Glycoprotein 75; Melanoma antigen gp75; MGC120175; MGC149362; RP11-3L8.1; TRP; TRY1; TRY4; TRYP1; Tyrosinase-related protein 1
基因别名: b-PROTEIN; CAS2; CATB; GP75; OCA3; TRP; TRP1; TYRP; TYRP1; TYRRP
UniProt ID: (Human) P17643
Entrez Gene ID: (Human) 7306
