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Tankyrase Antibody (PA5-30933) in IHC (P)
Tankyrase Polyclonal Antibody detects TNKS protein at cytosol on human hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded hepatoma. Tankyrase Polyclonal Antibody (Product # PA5-30933) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-30933
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 75 and 367 of Human Tankyrase
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2548407
产品详细信息
Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (92%), Chicken (93%), Rhesus Monkey (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADP-ribosyltransferase diphtheria toxin-like 5; ARTD5; HGNC:11941; Poly [ADP-ribose] polymerase 5A; Poly [ADP-ribose] polymerase tankyrase-1; Protein poly-ADP-ribosyltransferase tankyrase-1; TANK1; Tankyrase I; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; Tankyrase-1; TNKS-1; TRF1-interacting ankyrin-related ADP-ribose polymerase; TRF1-interacting ankyrin-related ADP-ribose polymerase 1
基因别名: ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1; TINF1; TNKS; TNKS1
UniProt ID: (Human) O95271
Entrez Gene ID: (Human) 8658
protein polyubiquitination
protein ADP-ribosylation
mitotic spindle organization
mitotic nuclear division
protein transport
Wnt signaling pathway
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
regulation of telomere maintenance via telomerase
positive regulation of telomere maintenance via telomerase
positive regulation of transcription from RNA polymerase II promoter
mRNA transport
spindle assembly
cell division
positive regulation of telomerase activity
protein localization to chromosome, telomeric region
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
positive regulation of canonical Wnt signaling pathway
positive regulation of telomere capping
negative regulation of telomere maintenance via telomere lengthening
negative regulation of telomeric DNA binding
negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
