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产品信息
PA5-52382
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2648216
产品详细信息
Immunogen sequence: QEGTYLATIH LPYLQGQVTL ELAVYKPPKV SLMPATLARA APGEAPPELL CLVSHFYPSG GLEVEWELRG GPGGRSQKAE GQRWLSALRH HSDGSVSLSG HLQPPPVTTE QHGARYACRI HHPS
Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 77%.
靶标信息
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DADB-159G18.7; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin; TPN
基因别名: NGS17; TAPA; TAPBP; TPN; TPSN
UniProt ID: (Human) O15533
Entrez Gene ID: (Human) 6892
antigen processing and presentation of peptide antigen via MHC class I
protein complex assembly
retrograde vesicle-mediated transport, Golgi to ER
immune response
regulation of gene expression
antigen processing and presentation of endogenous peptide antigen via MHC class I
peptide antigen stabilization
transmembrane transport
regulation of protein complex stability
