Invitrogen

Thymidine Phosphorylase Polyclonal Antibody

Thymidine Phosphorylase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Thymidine Phosphorylase Antibody (PA5-27291) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Oral CA SCC25 xenograft, using TYMP (Product # PA5-27291) antibody at 1:100 dilution. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

Thymidine Phosphorylase Antibody in Western Blot (WB)

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产品信息

PA5-27291

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:1,000

产品规格

种属反应

Human

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 1 and 338 of Human PD-ECGF

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 10% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2544767

产品详细信息

Recommended positive controls: NCI-H929.

Predicted reactivity: Mouse (85%), Rat (85%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

A platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

VLA4-Enhanced Allogeneic Endothelial Progenitor Cell-Based Therapy Preserves the Aortic Valve Function in a Mouse Model of Dyslipidemia and Diabetes.

Pharmaceutics

Filippi A,Constantin A,Alexandru N,Mocanu CA,Vlad ML,Fenyo IM,Simionescu A,Simionescu DT,Manduteanu I,Georgescu A

PA5-27291 was used in Immunohistochemistry to show that genetically modified allogeneic EPCs might be a safe treatment option, with bioavailability in the desired target compartments and the ability to preserve aortic valve function in dyslipidemia and diabetes.

Tue May 17 00:00:00 UTC 2022

生物信息学

蛋白别名: Gliostatin; OTTHUMP00000196767; OTTHUMP00000196770; PD TP; PD-ECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP

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基因别名: ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; TP; TYMP

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UniProt ID: (Human) P19971

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Entrez Gene ID: (Human) 1890

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功能

phosphorylase activity platelet-derived growth factor receptor binding growth factor activity thymidine phosphorylase activity pyrimidine-nucleoside phosphorylase activity transferase activity, transferring pentosyl groups glycosyltransferase

参与通路

mitochondrial genome maintenance angiogenesis pyrimidine nucleobase metabolic process pyrimidine nucleotide metabolic process DNA replication chemotaxis cell differentiation pyrimidine nucleoside salvage pyrimidine nucleoside catabolic process