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Invitrogen
Thymidylate Synthase Recombinant Rabbit Monoclonal Antibody (JM33-20)
Product Details
MA5-32733
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JM33-20
Immunogen
Synthetic peptide within Human Thymidylate Synthase aa 264-313
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2810010
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC88736; Thymidylate synthase; TS; TSase; tysy
Gene Aliases: HST422; OK/SW-cl.29; TMS; TS; TYMS
UniProt ID: (Human) P04818, (Mouse) P07607, (Rat) P45352
Entrez Gene ID: (Human) 7298, (Mouse) 22171, (Rat) 29261
G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
nucleobase-containing compound metabolic process
dTMP biosynthetic process
dTTP biosynthetic process
aging
circadian rhythm
cell proliferation
deoxyribonucleoside monophosphate biosynthetic process
response to toxic substance
cell growth
immortalization of host cell by virus
uracil metabolic process
organ regeneration
methylation
response to progesterone
response to vitamin A
response to cytokine
tetrahydrofolate interconversion
response to drug
response to ethanol
dUMP metabolic process
pyrimidine nucleoside biosynthetic process
response to organophosphorus
developmental growth
cartilage development
response to glucocorticoid
response to folic acid
intestinal epithelial cell maturation
DNA biosynthetic process
nucleotide biosynthetic process
pyrimidine nucleobase metabolic process
response to organic cyclic compound
tetrahydrofolate metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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