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产品信息
PA5-100211
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TTN(Accession Q8WZ42), corresponding to amino acid residues N2664-K2714.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815741
产品详细信息
Antibody detects endogenous levels of total TITIN.
靶标信息
Monoclonal Anti-Titin can be used for study of the elastic filaments within sarcomeric structures. It is also useful as a differentiation marker in the separation of rhabdomyosarcomas from other muscle tumors. By indirect immunofluorescence the antibody displays a typical striated staining pattern on frozen sections of chicken skeletal and cardiac muscle tissues. Stains the region of the A-I junction by indirect immunofluorescence. It shows a decoration line 0.05 mm from the end of the A band in electron micro-graphs. In immunoblotting using total extracts of chicken breast muscle the antibody reacts specifically with both bands of the titin doublet, and showed no reaction with nebulin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2.7.11.1; Connectin; DKFZp451N061; FLJ26020; FLJ26409; FLJ32040; FLJ34413; FLJ39564; FLJ43066; Rhabdomyosarcoma antigen MU-RMS-40.14; Titin; titin protein homolog; ttn
基因别名: 1100001C23Rik; 2310036G12Rik; 2310057K23Rik; 2310074I15Rik; AF006999; AV006427; CMD1G; CMH9; CMPD4; D330041I19Rik; D830007G01Rik; EOMFC; HMERF; L56; LGMD2J; mdm; MYLK5; shru; TMD; TTN
UniProt ID: (Human) Q8WZ42
Entrez Gene ID: (Human) 7273, (Rat) 84015, (Mouse) 22138
protease binding
protein serine/threonine kinase activity
protein tyrosine kinase activity
calcium ion binding
protein binding
calmodulin binding
ATP binding
structural constituent of muscle
enzyme binding
protein kinase binding
telethonin binding
identical protein binding
actinin binding
protein self-association
actin filament binding
muscle alpha-actinin binding
structural molecule activity conferring elasticity
structural constituent of cytoskeleton
immunoglobulin receptor superfamily
platelet degranulation
cardiac muscle hypertrophy
muscle contraction
striated muscle contraction
mitotic chromosome condensation
peptidyl-tyrosine phosphorylation
muscle filament sliding
skeletal muscle thin filament assembly
skeletal muscle myosin thick filament assembly
detection of muscle stretch
sarcomere organization
regulation of protein kinase activity
cardiac muscle fiber development
sarcomerogenesis
regulation of catalytic activity
response to calcium ion
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
cardiac muscle contraction
in utero embryonic development
heart morphogenesis
adult heart development
ventricular system development
forward locomotion
striated muscle cell development
heart growth
