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NeoBiotechnologies
Topoisomerase I Mitochondrial (TOP1MT) Recombinant Mouse Monoclonal Antibody (rTOP1MT/488)
产品信息
116447-MSM5-P1
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
rTOP1MT/488
抗原
Recombinant full-length human TOP1MT protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: MCF-7 or A431 cells. Jurkat cell lysate. Human heart, skeletal muscle, brain or fetal liver tissue. Cellular Localization: Cytoplasm (Mitochondria)
Specificity Comments: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
靶标信息
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA topoisomerase I; DNA topoisomerase I, mitochondrial; mitochondrial topoisomerase IB; TOP1M; TOP1mt; Topoisomerase I mitochondrial; Type IB Topoisomerase
基因别名: TOP1MT
UniProt ID: (Human) Q969P6
Entrez Gene ID: (Human) 116447
