Invitrogen

Transferrin Receptor Monoclonal Antibody (MEM-75), PE

Transferrin Receptor Antibody in Flow Cytometry (Flow)

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Transferrin Receptor Antibody (MA1-19640) in Flow

Flow cytometry analysis (surface staining) of CD71 in K562 cells (red) and human lymphocytes (negative, grey) using anti-CD71 (MEM-75) PE Monoclonal antibody (Product # MA1-19640).

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产品信息

MA1-19640

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

20 µL/ 10^6 cells

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

MEM-75

抗原

Pre-B cell line NALM-6.

查看免疫原

偶联物

PE PE PE

激发/发射光谱

565/576 nm 查看光谱

形式

Liquid

纯化类型

Size-exclusion chromatography

保存液

PBS, pH 7.4, with 0.2% BSA

内含物

15mM sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

AB_1073345

产品详细信息

This antibody reacts with an extracellular epitope of CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes.

The antibody MEM-75 does not block binding of transferrin to the receptor.

靶标信息

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

仅用于科研。不用于诊断过程。未经明确授权不得转售。