Invitrogen

Transthyretin Polyclonal Antibody

Transthyretin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Transthyretin Antibody (PA5-80197) in IHC (P)

Immunohistochemistry analysis of Transthyretin on paraffin-embedded mouse pancreas tissue. Sample was incubated with Transthyretin polyclonal antibody (Product# PA5-80197).

Transthyretin Antibody in Western Blot (WB)

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产品信息

PA5-80197

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL

产品规格

种属反应

Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E.coli-derived rat Prealbumin recombinant protein (Position: G21-N147).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5mg BSA

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2747311

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

靶标信息

Transthyretin (TTR), generally called prealbumin, is a plasma protein that plays an important role in physiology such as a transporter of hormone thyroxine and retinal-binding protein. After produced primarily in the liver, TTR is excreted into the plasma. TTR represents a disproportionate fraction (25%) of CSF protein, prompting the suggestion that it is either selectively transported across the blood-CSF barrier or synthesized de novo within the central nervous system. Transthyretin is a constituent found to the neuritic plaques, neurofibrillary tangles, and microangiopathic lesions of senile cerebral amyloid. It has been reported that more than 40 different mutations in the TTR gene associated with amyloid deposition.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition.

Biology open

Prater M,Hamilton RS,Wa Yung H,Sharkey AM,Robson P,Abd Hamid NE,Jauniaux E,Charnock-Jones DS,Burton GJ,Cindrova-Davies T

PA5-80197 was used in Western Blot to study the effect of differential transcript expression across the first-second trimester transition on the human placenta.

Tue Jun 15 00:00:00 UTC 2021

RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition.

Biology open

Prater M,Hamilton RS,Wa Yung H,Sharkey AM,Robson P,Abd Hamid NE,Jauniaux E,Charnock-Jones DS,Burton GJ,Cindrova-Davies T

PA5-80197 was used in Western Blot to study the effect of differential transcript expression across the first-second trimester transition on the human placenta.

Tue Jun 15 00:00:00 UTC 2021

Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus.

Fluids and barriers of the CNS

Ojeda-Pérez B,Campos-Sandoval JA,García-Bonilla M,Cárdenas-García C,Páez-González P,Jiménez AJ

PA5-80197 was used in Immunohistochemistry (Paraffin), Western Blot to identify possible biomarkers of hydrocephalus in the cerebral grey and white matter. In the white matter, OPCs could be reacting to acquire a neuroprotective role or as a delay in the oligodendrocyte maturation.

Fri Jul 02 00:00:00 UTC 2021

Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone.

Nature biomedical engineering

Reshke R,Taylor JA,Savard A,Guo H,Rhym LH,Kowalski PS,Trung MT,Campbell C,Little W,Anderson DG,Gibbings D

PA5-80197 was used in Western Blot to show that small extracellular vesicles that efficiently package siRNA can significantly reduce its therapeutic dose.