Invitrogen

Triadin Polyclonal Antibody

Triadin Antibody in Immunocytochemistry (ICC/IF)

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Triadin Antibody (PA5-58304) in ICC/IF

Immunofluorecent analysis of Triadin in human cell line A-431 using Triadin Polyclonal Antibody (Product # PA5-58304). Staining shows localization to plasma membrane and cytosol.

Triadin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Triadin Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-58304

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:500

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human Triadin. Recombinant protein control fragment (Product #RP-95726).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2648904

产品详细信息

Immunogen sequence: VSTRKESLQL HNVTKAEKPA RVSKDVEDVP ASKKAKEGTE DVSPTKQKSP ISFFQCVYLD GYNGYGFQFP

Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 60%.

靶标信息

The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR’s) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR’s), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR’s and RyR’s. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae.

仅用于科研。不用于诊断过程。未经明确授权不得转售。