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Product Details
MA5-37489
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
185CT47.6.1
Immunogen
NTRK1 recombinant protein
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897422
Target Information
NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781I14186; EC 2.7.10.1; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1
Gene Aliases: C80751; Ntrk1; Tkr; trk; TrkA
UniProt ID: (Mouse) Q3UFB7
Entrez Gene ID: (Mouse) 18211
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
neurotrophin receptor activity
neurotrophin p75 receptor binding
protein binding
ATP binding
nerve growth factor receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase binding
protein homodimerization activity
ephrin receptor binding
nerve growth factor binding
transmembrane signal receptor
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
nervous system development
axon guidance
learning or memory
programmed cell death involved in cell development
response to activity
phosphorylation
peptidyl-tyrosine phosphorylation
sensory perception of pain
cell differentiation
B cell differentiation
response to nutrient levels
response to nicotine
nerve growth factor signaling pathway
mechanoreceptor differentiation
response to drug
positive regulation of programmed cell death
negative regulation of neuron apoptotic process
positive regulation of angiogenesis
protein autophosphorylation
neurotrophin TRK receptor signaling pathway
sympathetic nervous system development
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of NF-kappaB transcription factor activity
response to electrical stimulus
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
Sertoli cell development
innervation
axonogenesis involved in innervation
behavioral response to formalin induced pain
cellular response to nicotine
cellular response to growth factor stimulus
negative regulation of neuron death
cellular response to nerve growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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