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产品信息
PA5-121540
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Met1-Asp103 linked with Leu142-Gln187 (Accession P19237), with N-terminal His Tag
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2915112
靶标信息
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
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生物信息学
蛋白别名: Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); DKFZp451O223; Tpn1; troponin I type 1 (skeletal, slow); troponin I type 3 (cardiac); Troponin I, cardiac muscle; Troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform
基因别名: 2700018B22Rik; AI747285; CMD1FF; CMD2A; CMH7; cTnI; RCM1; SSTNI; Tn1; TNN1; TNNC1; TNNI1; TNNI3
UniProt ID: (Human) P19237, (Human) P19429, (Mouse) Q9WUZ5, (Mouse) P48787
Entrez Gene ID: (Human) 7135, (Human) 7137, (Mouse) 21952, (Mouse) 21954
skeletal muscle contraction
regulation of striated muscle contraction
transition between fast and slow fiber
muscle filament sliding
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
vasculogenesis
regulation of systemic arterial blood pressure by ischemic conditions
cellular calcium ion homeostasis
regulation of smooth muscle contraction
heart development
negative regulation of ATPase activity
heart contraction
regulation of cardiac conduction
regulation of muscle contraction
striated muscle contraction
