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UACA Antibody (PA5-121238) in WB
Western blot analysis of UACA in extracts of various cell lines. Samples were incubated with UACA Polyclonal antibody (Product # PA5-121238) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
产品信息
PA5-121238
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human UACA (NP_060473.2).
偶联物
形式
Liquid
浓度
2.28 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914810
产品详细信息
Positive test controls include: U-87MG, 293T, HT-1080, SKOV3. The target is usually found in the following locations: Cytoplasm, Nucleus, cytoskeleton.
Immunogen sequence: MKSLKSRLRR QDVPGPASSG AAAASAHAAD WNKYDDRLMK AAERGDVEKV TSILAKKGVN PGKLDVEGRS VFHVVTSKGN LECLNAILIH
靶标信息
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: nuclear membrane binding protein; nuclear membrane binding protein NUCLING; Nuclear membrane-binding protein; Nucling; uveal autoantigen with coiled coil domains and ankyrin repeats; Uveal autoantigen with coiled-coil domains and ankyrin repeats
基因别名: 2700059D02Rik; KIAA1561; NUCLING; RGD1560011; UACA
UniProt ID: (Human) Q9BZF9, (Mouse) Q8CGB3
Entrez Gene ID: (Human) 55075, (Mouse) 72565, (Rat) 315732
intrinsic apoptotic signaling pathway in response to DNA damage
intrinsic apoptotic signaling pathway in response to oxidative stress
response to UV
positive regulation of protein import into nucleus
negative regulation of NF-kappaB import into nucleus
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of inflammatory response
apoptotic signaling pathway
regulation of NIK/NF-kappaB signaling
biological_process
