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产品信息
H00053347-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
UBASH3A (AAH28138.1, 1 a.a. approximately 451 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAAGETQLYA KVSNKLKGRS SPSLLEPLLA MGFPVHTALK ALAATGRKTA EEALAWLHDH CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESKRQCA KNRAHEVFPH VTLCDFFTCE DQKVECLYEA LKRAGDRLLG SFPTAVPLAL HSSISYLGFF VSGSPADVIR EFAMTFATEA SLLADCSVKP CTKQLHLTLA HKFYPHHQRT LEQLARAIPL GHSCQWTAAL YSRDMRFVHY QTLRALFQYK PQNVDELTLS PGDYIFVDPT QQDEASEGWV IGISQRTGCR GFLPENYTDR ASESDTWVKH RMYTFSLATD LNSRKDGEAS SRCSGEFLPQ TARSLSSLQA LQATVARKSV LVVRHGERVD QIFGKAWLQQ CSTPDGNYYR PDLNFPCSLP RRSRGIKDFE NDPPLSSCGI FQSRIAGMFE DCLVGKVTIT ATLIMASRHP A
靶标信息
TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one SH3 domain and one UBA domain. Expressed at high levels in thymus, bone marrow, spleen and peripheral blood leukocytes, TULA exists as either a homodimer or a homo-oligomer that interferes with the degradation of receptor-type tyrosine kinases and promotes the accumulation of activated receptors on the cell surface. Additionally, TULA is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, which maps to human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms of TULA are produced due to alternative splicing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cbl-interacting protein 4; CLIP4; STS-2; Suppressor of T-cell receptor signaling 2; T-cell ubiquitin ligand 1; T-cell ubiquitin ligand protein; TULA-1; TULA1; Ubiquitin-associated and SH3 domain-containing protein A
基因别名: CLIP4; STS-2; STS2; TULA; TULA-1; UBASH3A
UniProt ID: (Human) P57075
Entrez Gene ID: (Human) 53347
