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UBE2B Antibody (MA5-42490) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human fetal skeletal muscle tissue using UBE2B Recombinant Monoclonal Antibody (Product # MA5-42490). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the UBE2B... View More
产品信息
MA5-42490
产品规格
种属反应
Human,
Zebrafish
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE56-12
抗原
Synthetic peptide within N-terminal Human Ube2B
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2911631
产品详细信息
Positive Control: A431 cell lysate, THP-1 cell lysate, HepG2 cell lysate, zebrafish tissue lysates, human breast carcinoma tissue, human fetal skeletal muscle tissue.
Subcellular Location: Nucleus, Cell membrane.
靶标信息
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2B is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E2 protein; E2 ubiquitin-conjugating enzyme B; HR6B; RAD6 homolog B; Ubiquitin carrier protein B; ubiquitin conjugating enzyme E2B; Ubiquitin-conjugating enzyme E2 B; Ubiquitin-conjugating enzyme E2-17 kDa; ubiquitin-conjugating enzyme E2B (RAD6 homolog); Ubiquitin-protein ligase B
基因别名: E2-17kDa; HHR6B; HR6B; RAD6B; UBC2; UBCH1; UBE2B; zgc:100921
UniProt ID: (Human) P63146
Entrez Gene ID: (Human) 7320, (Zebrafish) 437020
protein polyubiquitination
in utero embryonic development
DNA repair
postreplication repair
maintenance of chromatin silencing
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
spermatogenesis
sperm axoneme assembly
response to UV
positive regulation of reciprocal meiotic recombination
protein ubiquitination
negative regulation of histone phosphorylation
histone H2A ubiquitination
response to drug
DNA damage response, detection of DNA damage
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cAMP-mediated signaling
meiotic telomere clustering
protein stabilization
chiasma assembly
protein autoubiquitination
canonical Wnt signaling pathway
histone lysine demethylation
synaptonemal complex organization
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K11-linked ubiquitination
histone ubiquitination
