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UBE2D3 Antibody (PA5-42280) in WB
Western blot analysis of recombinant protein cells using an anti-UBE2D3 polyclonal antibody (Product # PA5-42280). Primary Antibody Dilution: 1:500; Secondary Antibody: Anti-rabbit-HRP; Secondary Antibody Dilution: 1:50,000. LANE 1) 40 ng HIS-UBE2D1 protein; LANE 2) 40 ng HIS-UBE2D2 protein; LANE 3) 40 ng HIS-UBE2D3 protein; LANE 4) 40 ng HIS-UBE2D4 protein; LANE 5) 40 ng HIS-UBE2E1 protein; LANE 6) 40 ng HIS-UBE2E2 protein; LANE 7) 40 ng HIS-UBE2E3 protein; LANE 8) 40 ng HIS-UBE2K protein; LANE 9) 40 ng HIS-UBE2L3 protein; LANE 10) 40 ng ... View More
产品信息
PA5-42280
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human UBE2D3 (aa 1-50).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2608401
产品详细信息
Peptide sequence: MALKRINKEL SDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%; Yeast: 92%; Zebrafish: 92%
靶标信息
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: (E3-independent) E2 ubiquitin-conjugating enzyme D3; E2 ubiquitin-conjugating enzyme D3; E2(17)KB 3; MGC43926; MGC5416; PRO2116; Ubiquitin carrier protein D3; ubiquitin conjugating enzyme E2D 3; Ubiquitin-conjugating enzyme E2 D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5); ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast); Ubiquitin-protein ligase D3
基因别名: E2(17)KB3; UBC4/5; UBC5C; UBCH5C; UBE2D3
UniProt ID: (Human) P61077
Entrez Gene ID: (Human) 7323
negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
DNA repair
cellular protein modification process
ubiquitin-dependent protein catabolic process
protein monoubiquitination
apoptotic process
protein ubiquitination
BMP signaling pathway
TRIF-dependent toll-like receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
regulation of transcription from RNA polymerase II promoter in response to hypoxia
protein K48-linked ubiquitination
protein K11-linked ubiquitination
positive regulation of protein targeting to mitochondrion
