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产品信息
PA1-41467
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues 12-28 of human UBE2V2.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS with 0.2% gelatin
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2211663
产品详细信息
Suggested positive control: HL-60, antigen standard for UBE2V2 (transient overexpression lysate).
靶标信息
The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2p and human CROC-1), which defines a structurally and functionally conserved Ubc-like protein family. This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is required together with Ubc13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains (4,5) UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the Mms2/Ubc13 heterodimer is necessary for DNA repair.
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生物信息学
蛋白别名: 1 alpha,25-dihydroxyvitamin D3-inducible; DDVit 1; EDAF-1; EDPF-1; enterocyte differentiation promoting factor; Enterocyte differentiation-associated factor 1; enterocyte differentiation-associated factor EDAF-1; Enterocyte differentiation-promoting factor 1; meth; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of; MMS2 homolog; ubiquitin conjugating enzyme E2 variant 2; Ubiquitin-conjugating enzyme E2 variant 2; Vitamin D3-inducible protein
基因别名: DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1; MMS2; UBE2V2; UEV-2; UEV2
UniProt ID: (Human) Q15819
Entrez Gene ID: (Human) 7336
protein polyubiquitination
DNA double-strand break processing
regulation of DNA repair
postreplication repair
double-strand break repair via nonhomologous end joining
cell proliferation
positive regulation of neuron projection development
protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
error-free postreplication DNA repair
negative regulation of neuron apoptotic process
positive regulation of DNA repair
positive regulation of synapse assembly
protein K63-linked ubiquitination
global genome nucleotide-excision repair
