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UBE3C Antibody (PA5-110540) in WB
Journal of translational medicine 2023 -
Fig. 2 UBE3C knockdown enhances radiosensitivity of BRCA cells. A, RT-qPCR and WB analyses for mRNA ( A ) and protein ( B ) levels of UBE3C in MDA-MB-231 and SK-BR-3 cells (R and Pa) after sh-UBE3C or oe-UBE3C transfection; C sensitivity of MDA-MB-231 and SK-BR-3 cells (R and Pa) to different doses of irradiation ( 0, 2, 4, 8, and 12 Gy) analyzed by the CTG kit; D , number of colonies formed by R or Pa BRCA... View More
产品信息
PA5-110540
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 970-1083 of human UBE3C (NP_0554862)
偶联物
形式
Liquid
浓度
0.81 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855951
产品详细信息
Immunogen sequence: PISLEDLKSF TNYSGGYSAD HPVIKVFWRV VEGFTDEEKR KLLKFVTSCS RPPLLGFKEL YPAFCIHNGG SDLERLPTAS TCMNLLKLPE FYDETLLRSK LLYAIECAAG FELS
靶标信息
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HECT-type ubiquitin transferase E3C; HectH2; Homologous to E6AP carboxyl terminus homologous protein 2; RAUL; RTA-associated ubiquitin ligase; ubiquitin-protein isopeptide ligase (E3); Ubiquitin-protein ligase E3C
基因别名: HECTH2; KIAA0010; KIAA10; UBE3C
UniProt ID: (Human) Q15386
Entrez Gene ID: (Human) 9690
