Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-110384
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human SLC25A27 (NP_001190981.1).
偶联物
形式
Liquid
浓度
1.75 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855795
产品详细信息
Immunogen sequence: MSVPEEEERL LPLTQRWPRA SKFLLSGCAA TVAELATFPL DLTKTRLQMQ GEAALARLGD GARESAPYRG MVRTALGIIE EEGFLKLWQG VTPAIYRHVV YSGGRMVTYE HLREVVFGKS EDEHYPLWKS VIGGMMAGVI GQFLANPTDL VKVQMQMEGK RKLEGKPLRF RGVHHAFAKI LAEGGIRGLW AGWVPNIQRA ALVNMGDLTT YDTVKHYLVL NTPLEDNIMT HGLSSDLVGS HKAIQ
靶标信息
UCP4 is a 323 amino acid mitochondrial uncoupling protein belonging to the large mitochondrial substrate carrier family with three Solcar repeats. UCP4 is a mitochondrial transport carrier that facilitates the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. It reduces the mitochondrial membrane potential in mammalian cells and is involved in thermoregulatory heat production. UCP4 creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis resulting in dissipation of energy in the form of heat. UCP4 is usually found in adult and fetal brain, with low levels in spinal chord, corpus callosum and substantia nigra.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Mitochondrial uncoupling protein 4; Solute carrier family 25, member 27; UCP 4; uncoupling protein; uncoupling protein UCP-4
基因别名: 3632410G24Rik; 9430092A03Rik; D530043E16Rik; Slc25a27; UCP4
UniProt ID: (Mouse) Q9D6D0
Entrez Gene ID: (Mouse) 74011, (Rat) 85262
positive regulation of cell proliferation
negative regulation of mitochondrial membrane potential
cellular triglyceride homeostasis
negative regulation of apoptotic process
regulation of glucose import
negative regulation of mitochondrial calcium ion concentration
neuron death
transport
inner ear development
