Invitrogen

UCP4 Polyclonal Antibody

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UCP4 Antibody (PA5-69265) in WB

Western blot analysis of UCP4 on mouse brain tissue lysate. The sample was probed with a UCP4 polyclonal antibody (Product # PA5-69265) using a primary antibody dilution of 1.0 µg/mL.

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产品信息

PA5-69265

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1.0 µg/mL

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产品规格

种属反应

Mouse

已发表种属

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide corresponding to a region of mouse UCP4

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2691117

产品详细信息

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 85%

靶标信息

UCP4 is a 323 amino acid mitochondrial uncoupling protein belonging to the large mitochondrial substrate carrier family with three Solcar repeats. UCP4 is a mitochondrial transport carrier that facilitates the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. It reduces the mitochondrial membrane potential in mammalian cells and is involved in thermoregulatory heat production. UCP4 creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis resulting in dissipation of energy in the form of heat. UCP4 is usually found in adult and fetal brain, with low levels in spinal chord, corpus callosum and substantia nigra.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The Effects of Prenatal Dexamethasone Exposure on Brain Metabolic Homeostasis in Adulthood: Implications for Depression.

International journal of molecular sciences

Głombik K,Kukla-Bartoszek M,Curzytek K,Detka J,Basta-Kaim A,Budziszewska B

PA5-69265 was used in Western Blotting to examine a possible association between brain energetic changes induced by synthetic glucocorticoid-dexamethasone treatment in the prenatal period and depressive-like behavior.

Fri Jan 06 00:00:00 UTC 2023

Brain Metabolic Alterations in Rats Showing Depression-Like and Obesity Phenotypes.

Neurotoxicity research

Głombik K,Detka J,Góralska J,Kurek A,Solnica B,Budziszewska B

PA5-69265 was used in Western Blot to examine the changes in glucose metabolism markers in the brain of rats with obesity, depression and co-occurrence phenotypes.