Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 4
UGT8 Antibody (PA5-48251) in IHC (P)
Immunohistochemistry analysis of UGT8 in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with UGT8 polyclonal antibody (Product # PA5-48251) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-48251
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 366-393 amino acids from the Central region of human UGT8.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2633709
Product Specific Information
Predicted to react with rat based on sequence homology.
Target Information
UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase 8A; UDP-glucuronosyltransferase 8; uridine diphosphate glycosyltransferase 8
Gene Aliases: AI850488; AW455908; CGT; mCerGT; UGT4; UGT8; Ugt8a
UniProt ID: (Human) Q16880, (Mouse) Q64676
Entrez Gene ID: (Human) 7368, (Mouse) 22239
2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
glucuronosyltransferase activity
N-acylsphingosine galactosyltransferase activity
ceramide glucosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
protein localization to paranode region of axon
lipid metabolic process
sphingolipid metabolic process
cytoskeleton organization
metabolic process
glycolipid biosynthetic process
flavonoid biosynthetic process
paranodal junction assembly
cellular response to hormone stimulus
myelination
neuron projection morphogenesis
flavonoid glucuronidation
galactosylceramide biosynthetic process
glycosphingolipid metabolic process
central nervous system development
peripheral nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support