Abnova

UMOD Polyclonal Antibody, MaxPab™

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UMOD Antibody (H00007369-D01P) in WB

Western Blot analysis of UMOD expression in transfected 293T cell line by UMOD MaxPab polyclonal antibody. Lane 1: UMOD transfected lysate(66.70 KDa). Lane 2: Non-transfected lysate. .

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产品信息

H00007369-D01P

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

UMOD (AAH35975.1, 1 a.a. approximately 611 a.a) full-length human protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MGQPSLTWML MVVVASWFIT TAATDTSEAR WCSECHSNAT CTEDEAVTTC TCQEGFTGDG LTCVDLDECA IPGAHNCSAN SSCVNTPGSF SCVCPEGFRL SPGLGCTDVD ECAEPGLSHC HALATCVNVV GSYLCVCPAG YRGDGWHCEC SPGSCGPGLD CVPEGDALVC ADPCQAHRTL DEYWRSTEYG EGYACDTDLR GWYRPHPSSD EGIVSRKACA HWSGHCCLWD ASVQVKACAG GYYVYNLTAP PECHLAYCTD PSSVEGTCEE CSIDEDCKSN NGRWHCQCKQ DFNITDISLL EHRLECGAND MKVSLGKCQL KSLGFDKVFM YLSDSRCSGF NDRDNRDWVS VVTPARDGPC GTVLTRNETH ATYSNTLYLA DEIIIRDLNI KINFACSYPL DMKVSLKTAL QPMVSALNIR VGGTGMFTVR MALFQTPSYT QPYQGSSVTL STEAFLYVGT MLDGGDLSRF ALLMTNCYAT PSSNATDPLK YFIIQDRCPH TRDSTIQVVE NGESSQGRFS VQMFRFAGNY DLVYLHCEVY LCDTMNEKCK PTCSGTRFRS GSVIDQSRVL NLGPITRKGV QATVSRAFSS LGLLKVWLPL LLSATLTLTF Q

靶标信息

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

仅用于科研。不用于诊断过程。未经明确授权不得转售。