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UNC5B Antibody (PA5-120319) in WB
Western blot analysis of UNC5B in extracts of various cell lines. Samples were incubated with UNC5B Polyclonal antibody (Product # PA5-120319) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-120319
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 290-377 of human UNC5B (NP_734465.2).
偶联物
形式
Liquid
浓度
0.99 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2913891
产品详细信息
Positive test controls include: U-87MG, A-549, 293T, Mouse brain, Mouse lung, Mouse kidney, Rat brain, Rat lung. The target is usually found in the following locations: Cell membrane, Membrane raft, Single-pass type I membrane protein.
Immunogen sequence: FQKTACTTIC PVDGAWTEWS KWSACSTECA HWRSRECMAP PPQNGGRDCS GTLLDSKNCT DGLCMQNKKT LSDPNSHLLE ASGDAALY
靶标信息
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C. elegans; Netrin receptor UNC5B; p53-regulated receptor for death and life protein 1; p53RDL1; Protein unc-5 homolog 2; Protein unc-5 homolog B; transmembrane receptor Unc5H2; unc-5 homolog 2; unc-5 homolog B; unc5 homolog 2
基因别名: 6330415E02Rik; A630020F16; D10Bwg0792e; P53RDL1; UNC5B; UNC5H2; UNQ1883/PRO4326
UniProt ID: (Human) Q8IZJ1, (Mouse) Q8K1S3, (Rat) O08722
Entrez Gene ID: (Human) 219699, (Mouse) 107449, (Rat) 60630
angiogenesis
apoptotic process
signal transduction
positive regulation of phosphatidylinositol 3-kinase signaling
anterior/posterior axon guidance
negative regulation of neuron apoptotic process
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
multicellular organism development
axon guidance
netrin-activated signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
