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产品信息
PA5-30917
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 302 and 483 of Human UNC5CL
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2548391
产品详细信息
Recommended positive controls: Raji.
Predicted reactivity: Human (99%), Mouse (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
UNC5CL is a membrane protein belonging to theUNC-5 family with a death domain and a ZU5 domain and is known to interact with p65/RELA and NFKB1. UNC5CL is known to interact with subunit p105 of NF-kappaB and transactivator p65 and is thus involved in inhibition of NF-kappaB activation and NF-kappaB-dependent transcription by inhibiting the binding of NF-kappaB to its target sequence (providing an alternative regulatory mechanism for NF-kappaB-mediated transcription). This regulatory protein sensitizes cells to apoptosis induced by TNF and TRAIL.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC34763; OTTHUMP00000016362; Protein unc-5 homolog C-like; unc-5 homolog C (C. elegans)-like; UNC5C-like protein; zu-5; ZU5 and death domain containing; ZU5 and death domain-containing protein
基因别名: MUXA; UNC5CL; ZUD
UniProt ID: (Human) Q8IV45
Entrez Gene ID: (Human) 222643
