Invitrogen

UNC93B1 Polyclonal Antibody

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UNC93B1 Antibody (PA5-90319) in WB

Western blot analysis of UNC93B1 in extracts of various cell lines. Samples were incubated with UNC93B1 Polyclonal antibody (Product # PA5-90319) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.

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产品信息

PA5-90319

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence within amino acids 450-550 of human UNC93B1 (NP_1121922)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.1 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2806025

产品详细信息

Immunogen sequence: KTGLSTLLGI LYEDKERQDF IFTIYHWWQA VAIFTVYLGS SLHMKAKLAV LLVTLVAAAV SYLRMEQKLR RGVAPRQPRI PRPQHKVRGY RYLEEDNSDE S; Positive Samples: 293T, HeLa, Mouse kidney, Mouse lung, Mouse spleen, Rat kidney, Rat lung, Rat spleen; Cellular Location: Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Multi-pass membrane protein, phagosome

靶标信息

The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。