Invitrogen

USP37 Polyclonal Antibody

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USP37 Antibody (PA5-31266) in WB

Western Blot using USP37 Polyclonal Antibody (Product # PA5-31266). Sample (30 µg of whole cell lysate). Lane A: 293T . 7.5% SDS PAGE. USP37 Polyclonal Antibody (Product # PA5-31266) diluted at 1:1,000.

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产品信息

PA5-31266

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:3,000

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 617 and 892 of Human USP37

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 1% BSA, 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2548740

产品详细信息

Recommended positive controls: 293T.

Predicted reactivity: Mouse (87%), Dog (91%), Bovine (94%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). [UniProt]

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The deubiquitinating enzyme USP37 promotes keloid fibroblasts proliferation and collagen production by regulating the c-Myc expression.

International wound journal

Piao M,Feng G

PA5-31266 was used in Western Blot to promote the proliferation and collagen deposit of keloid fibroblasts, and USP37 could be targeted in future keloid therapy.

Mon May 01 00:00:00 UTC 2023

The deubiquitinating enzyme USP37 promotes keloid fibroblasts proliferation and collagen production by regulating the c-Myc expression.

International wound journal

Piao M,Feng G

PA5-31266 was used in Western Blot to promote the proliferation and collagen deposit of keloid fibroblasts, and USP37 could be targeted in future keloid therapy.

Mon May 01 00:00:00 UTC 2023

生物信息学

蛋白别名: Deubiquitinating enzyme 37; tmp_locus_50; Ubiquitin carboxyl-terminal hydrolase 37; ubiquitin specific protease 37; Ubiquitin thioesterase 37; ubiquitin thiolesterase 37; Ubiquitin-specific-processing protease 37

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基因别名: KIAA1594; USP37

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UniProt ID: (Human) Q86T82

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Entrez Gene ID: (Human) 57695

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功能

cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding protein kinase binding cysteine protease

参与通路

G1/S transition of mitotic cell cycle ubiquitin-dependent protein catabolic process mitotic nuclear division protein deubiquitination protein K11-linked deubiquitination cell division protein K48-linked deubiquitination