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USP51 Antibody (PA5-68358) in WB
Molecular medicine reports 2020 -
Figure 4. Knockdown of USP51 decreases DDP resistance in A549/DDP cells by modulating ZEB1 ubiquitination. (A) After infection of ZEB1/vector lentivirus in A549/DDP cells, ZEB1 mRNA and protein levels were detected. (B) A549/DDP cells were infected with shUSP51 and ZEB1 lentiviruses and treated with 100 umol/l DDP, and apoptotic cells were detected. (C) ZEB1 mRNA expression in USP51-silenced A549/DDP cells ... View More
产品信息
PA5-68358
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human USP51.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2691902
产品详细信息
Predicted to react with Human, Mouse, and Rat samples.
靶标信息
USP51 (Ubiquitin Specific Peptidase 51) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Deubiquitinating enzyme 51; Ubiquitin carboxyl-terminal hydrolase 51; ubiquitin specific peptidase 51; ubiquitin specific protease 51; Ubiquitin thioesterase 51; ubiquitin thiolesterase 51; Ubiquitin-specific-processing protease 51
基因别名: AV136873; RGD1562211; USP51
UniProt ID: (Human) Q70EK9, (Mouse) B1AY15
Entrez Gene ID: (Human) 158880, (Mouse) 635253, (Rat) 317398
